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Bioperine, a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent of piperine. Bioperine is used in conjunction with other herbs or vitamins to increase their absorption and digestion to make them more effective.

Caffeine is the most widely available legal psychoactive stimulant drug. Also known as theine, methyltheobromine and trimethylxanthine, this xanthine alkaloid is not only found in coffee beans, but also in guaranine that is derived from guarana, mateine derived from mate, theine which is found in various teas and the kola nut, which is the base flavor of various Cola soft drinks. It stimulates the central nervous system, where it restores alertness and wards off drowsiness. Caffeine is also know to display certain diuretic properties, is an ergogenic, an atagonist of the adenosine receptors, and a cAMP levels increasing factor. It seems that caffeine helps prevent the onset of Parkinson’s disease and in the long run lowers the possibility of developing a heart disease.

Green Tea Extract increases energy expenditure and affects fat oxidation, which therefore promotes weight loss by increasing the body's metabolism.

Sclareolide, a fermented clary sage compound, is a plant terpenoid. Terpenoids are a diverse category of organic chemicals occurring in natural form. Sclareolide is a natural muscle relaxer and used to relieve backaches, muscle cramps as well as muscle spasms. Besides this, sclareolide also helps in maintaining and building lean body mass. Since it is known to have excellent thermogenic properties, it is widely used in weight loss supplements under the name of Norambrolide. It works by directly increasing cAMP levels and boosting the activity rate of lipolysis through the energy metabolism, Cyclic AMP. The best way for dieters to shed more body fat is to take a sclareolide dose in combination with a thermogenic supplement. This way, dieters can be assured of burning more calories easily.

Synephrine, a semi-selective sympathomimetic, is used to stimulate the adrenaline system. Also known as ‘zhi shi’, green orange or bitter orange; it is a chief, active constituent found in the fruit belonging to the plant, Citrus aurantium. Synephrine is not only similar to ephedra in its chemical composition but also serves the same benefits as caffeine or ephedrine. However, it mildly stimulates the fat metabolism without causing any of the side effects associated with ephedra based products. The best advantage of using Synephrine is that it increases the metabolic rate without affecting the hemodynamics. Thus, it is comparatively much safer than ephedra. Since Synephrine promotes weight loss and supports thermogenesis, Synephrine supplements are an ideal solution for dieters and weight watchers. The total intake should be between 2 to 10 mg. per day.

Synthetic Guggulsterones, which is a form of orally administered guggulipid, which increases T3 (tryiidothyronine) levels in animal models. T3 is the conversion product of T4, which is produced by the thyroid gland. Thyroid hormone levels are closely involved in metabolic function. Increased thyroid levels can cause more fat to be burned and stored. While on a diet, the body responds by decreasing T3 levels, therefor decreasing metabolic rate. It is not known how guggulipid increases T3 levels. Guggul, also called guggulipid, is an ethyl acetate extract of the gum resin of the guggul tree.

Vinpocetine, a derivative alkaloid of vincamine, is actually semi synthetic in nature. It is an extract from the It is an extract from the periwinkle vinca minor. Vinpocentine is used because it has neuroprotective effects and also helps in enhancing the cerebral blood flow. In Eastern Europe, it is also used as a drug to treat cerebrovascular disorders along with age related memory impairment. It is also extensively marketed as a supplement for vasodilation. It is also used to improve the memory since it plays the role of a nootropic. Vinpocentine is therefore used in supporting brain function. It helps in enhancing concentration and memory by activating cerebral metabolism. In the body building world, vinpocetine is often used a vasodilator. However, no research has been done so far on the effect of vinpocentine in the body building.

Yohimbe is an alkaloid and the active ingredient of a medicinal herb also known as Pausinystalia yohimbe, formerly named Corynanthe yohimbe. It is noted as a stimulant drug and also as an aphrodisiac. While the medicinal community has conducted numerous studies of yohimbe in conjunction with sexual dysfunctions, in veterinary medicine, yohimbine is employed as the antidode to anesthesia stemming from the drug xylazine in large and small animals. In recent times, yohimbine has been found to instigate fat loss in athletes when taken orally. There are also some formulations available, for a significant price, where yohimbine can be directly applied transdermally to adipose tissue, leading to a local reduction. This application is still in experimentation and should not be used without professional assistance.