Tight Reviewed

Bioperine is an extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) that contains 95 percent of piperine. Black pepper is a common household spice. Extract from black pepper has also been used extensively as a medicine. To reach the greatest quality during the harvest, the pepper is reaped before ripening and after that is placed to dry under the sun rays. Bioperine is known for its effect to enhance the efficiency of many supplement nutrients. Bioperine acts to enhance the body’s natural therogenic activity – giving the name thermonutrient. This enhancement brings about increased metabolic rate creating demand for supple of many nutrients such as vitamins, minerals, herbals, amino acids. It sets in motion a process that brings about better digestion and faster gastrointestinal absorption.

Caffeine may be the most popular legal addictive stimulant that is available to mankind. Besides coffee, tea, guarana and kola nut have excess amount of this xanthine alkaloid, which is actually acting as a psychoactive drug. In several plants, caffeine is an effective insect repellant, but this trimethylxanthine is deemed by the Food and Drug Administration as generally safe food substance. It is an antagonist of adenosine receptors. The effect of caffeine is individual and may more or less increase the ability to perform physical and mental labor. It reduces the effects of fatigue and may in long term help predominantly men reduce the risk of developing Parkinson’s disease. It has also been observed that caffeine has nootropic effects, furthermore, regular consumption of caffeine may significantly reduce the risk of heart diseases.

Green Tea Extract- By increasing the body's metabolism, it is widely believed that green tea extract largely aids in weight loss.

Sclareolide, which is thought to increase cAMP (cyclic adenosine monophosphate) levels in the body through the stimulation of the "adenylate cyclase" (AC) enzyme. This stimulation is believed to help activate increased fat burning.

Synephrine is an adrenergic amines and stimulant with beta-3 receptors. It functions to increase metabolic rate with no effect to heart rate or blood pressure. Synephrine releases adrenaline and noradrenalin in the adipose tissue and the liver. Stimulation of the beta-3 receptor sites to educe the breakdown of fat. It can be added to the group of stimulants, to which belong such supplements as caffeine or ephedrine. Can be used to boost energy, suppress appetite and enhance metabolic rate to burn more calories and increased the energy, but it does not cause so undesired negative cardiovascular effects. Its active ingredients include gelatin, cellulose, and silica and magnesium strearate. Its weight loss abilities are associated with citrus aurantium (synephrine) supplements which give it the stimulant like effects of the alkaloids.

Synthetic Guggulsterones is naturally found in the resin of the guggul plant, it is a plant sterol and the Latin name of the plant is Commiphora mukul. It is believed that in humans, an extract of the guggul plant functions as a farnesoid X receptor inhibitor, theoretically attributing to a diminished synthesis of cholesterol in the liver. It is a very popular nutritional supplement and exists in several synthetic variants which are popular with the body building communities. The most popular application is the one as a weight loss agent, but it has been observed that Synthetic Guggulsterones may also stimulate thyroid function directly. While there is a debate if synthetic or natural guggulsterones are to be preferred, the availability and price of Synthetic Guggulsterones is currently prevailing.

Vinpocetine, a derivative alkaloid of vincamine, is actually semi synthetic in nature. It is an extract from the It is an extract from the periwinkle vinca minor. Vinpocentine is used because it has neuroprotective effects and also helps in enhancing the cerebral blood flow. In Eastern Europe, it is also used as a drug to treat cerebrovascular disorders along with age related memory impairment. It is also extensively marketed as a supplement for vasodilation. It is also used to improve the memory since it plays the role of a nootropic. Vinpocentine is therefore used in supporting brain function. It helps in enhancing concentration and memory by activating cerebral metabolism. In the body building world, vinpocetine is often used a vasodilator. However, no research has been done so far on the effect of vinpocentine in the body building.

Yohimbe is an alkaloid and the active ingredient of a medicinal herb also known as Pausinystalia yohimbe, formerly named Corynanthe yohimbe. It is noted as a stimulant drug and also as an aphrodisiac. While the medicinal community has conducted numerous studies of yohimbe in conjunction with sexual dysfunctions, in veterinary medicine, yohimbine is employed as the antidode to anesthesia stemming from the drug xylazine in large and small animals. In recent times, yohimbine has been found to instigate fat loss in athletes when taken orally. There are also some formulations available, for a significant price, where yohimbine can be directly applied transdermally to adipose tissue, leading to a local reduction. This application is still in experimentation and should not be used without professional assistance.